Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion

Futao Wang; Xiangyun Zheng; Qi Zhao; Yuchen Feng; Guanyue Gao; Dalibor M. Stanković; Jinfang Zhi

doi:10.1080/26941112.2023.2300475

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Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion

Research Article | Updated：2025-01-22

- Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion
- Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion
- Functional Diamond 2024年4卷第1期
- Affiliations：
  
  1. b Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material Physics Ministry of Education School of Physics and Microelectronics Zhengzhou University
  2. a Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing People’s Republic of China
  3. c University of Chinese Academy of Sciences
  4. a Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences
  5. d Innovation Center of the Faculty of Chemistry University of Belgrade
- Author bio：
- Funds：
- DOI：10.1080/26941112.2023.2300475
  中图分类号：
- 网络首发：2024-02-10，
  
  纸质出版：2024
- Accepted：
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Futao Wang, Xiangyun Zheng, Qi Zhao, 等. Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion[J]. Functional Diamond, 2024,4(1).

Futao Wang, Xiangyun Zheng, Qi Zhao, et al. Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion[J]. Functional Diamond2024, 4(1).
Futao Wang, Xiangyun Zheng, Qi Zhao, 等. Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion[J]. Functional Diamond, 2024,4(1). DOI： 10.1080/26941112.2023.2300475.

Futao Wang, Xiangyun Zheng, Qi Zhao, et al. Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion[J]. Functional Diamond2024, 4(1). DOI： 10.1080/26941112.2023.2300475.

摘要

Abstract

Carbon-based nanomaterials have been explored as effective adsorbents to remove bilirubin in hemoperfusion therapy. However

developing carbon-based absorbents with both high adsorption capacity and good hemocompatibility remains a challenge in clinical applications. In this study

an efficient adsorbent for bilirubin removal was fabricated by grafting polyaniline (PANI) onto nanodiamonds (NDs). The nanocomposite ND-PANI had negligible effect on the hemolytic activity

confirming its excellent blood compatibility. The adsorption results revealed that the ND-PANI had high adsorption capacities (947 mg/g) and rapid adsorption rate toward bilirubin. Moreover

it exhibited efficient bilirubin adsorption in bovine serum albumin (BSA) solution

indicating its potential for practical application. Additionally

the adsorption kinetics and isotherms were systematically analyzed and modeled

thereby offering insights into the possible adsorption mechanism. Our findings suggest that the ND-PANI could be used as an efficient sorbent for the bilirubin removal

offering a promising avenue for blood purification application.

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references

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