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School of Engineering Institute for Bioengineering The University of Edinburgh
Online First:30 December 2021,
Published:2021
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Yuxiang Xue, Xue Feng, Samuel C. Roberts, et al. Diamond and carbon nanostructures for biomedical applications[J]. Functional Diamond2021, 1(1): 221-242.
Yuxiang Xue, Xue Feng, Samuel C. Roberts, et al. Diamond and carbon nanostructures for biomedical applications[J]. Functional Diamond2021, 1(1): 221-242. DOI: 10.1080/26941112.2021.2013716.
Diamond and carbon nanostructures possess outstanding advantages
such as chemical inertness
stable fluorescence
tunable surface characteristics and excellent biocompatibility. In particular
diamond has extremely strong mechanical properties
and therefore the nanostructures have been developed for unique applications. Herein
we systematically review the very recent applications of these structures in drug delivery
bioimaging and biosensing
followed by discussion of their advantages
limitations and challenges in translation to potential clinical applications and presentation of our insights of their future development.
Gupta T, Gupta T. Historical production and use of carbon materials: the activated carbon. In: Gupta T, editor. Carbon: the black, the gray and the transparent. Cham: Springer; 2018. p. 47–70. Google Scholar
Mathur RB, Singh BP, Pande S. Carbon nanomaterials: synthesis, structure, properties and applications. New York: CRC Press; 2016. Google Scholar
Falcao EHL, Wudl F. Carbon allotropes: beyond graphite and diamond. J Chem Technol Biotechnol. 2007;82(6):524–531. Web of Science ®Google Scholar
Hirsch A. The era of carbon allotropes. Nat Mater. 2010;9(11):868–871. PubMed Web of Science ®Google Scholar
Wang Y, Li Z, Wang J, et al. Graphene and graphene oxide: biofunctionalization and applications in biotechnology. Trends Biotechnol. 2011;29(5):205–212. PubMed Web of Science ®Google Scholar
Sankaran KJ, Haenen K. Properties of Carbon Bulk Materials. In Arnault J-C, Eder D, editors. Synthesis and Applications of Nanocarbons. Hoboken: Wiley; 2020. p. 1–23. Google Scholar
Kroto HW, Heath JR, O’Brien SC, et al. C 60: buckminsterfullerene. Nature. 1985;318(6042):162–163. Web of Science ®Google Scholar
Georgakilas V, Perman JA, Tucek J, et al. Broad family of carbon nanoallotropes: classification, chemistry, and applications of fullerenes, carbon dots, nanotubes, graphene, nanodiamonds, and combined superstructures. Chem Rev. 2015;115(11):4744–4822. PubMed Web of Science ®Google Scholar
Li B, Zhao S, Huang L, et al. Recent advances and prospects of carbon dots in phototherapy. Chem Eng J. 2021;408:127245. Web of Science ®Google Scholar
Li X, Zhao S, Li B, et al. Advances and perspectives in carbon dot-based fluorescent probes: mechanism, and application. Coord Chem Rev. 2021;431:213686. Web of Science ®Google Scholar
Lan M, Zhang J, Chui Y-S, et al. Carbon nanoparticle-based ratiometric fluorescent sensor for detecting mercury ions in aqueous media and living cells. ACS Appl Mater Interfaces. 2014;6(23):21270–21278. PubMed Web of Science ®Google Scholar
Zhao S, Wu S, Jia Q, et al. Lysosome-targetable carbon dots for highly efficient photothermal/photodynamic synergistic cancer therapy and photoacoustic/two-photon excited fluorescence imaging. Chem Eng J. 2020;388:124212. Web of Science ®Google Scholar
Chen X, Zhang W. Diamond nanostructures for drug delivery, bioimaging, and biosensing. Chem Soc Rev. 2017;46(3):734–760. PubMed Web of Science ®Google Scholar
Su L-X, Cao Y, Hao H-S, et al. Emerging applications of nanodiamonds in photocatalysis. Funct Diam. 2021;1(1):93–109. Google Scholar
Stachel T, Luth RW. Diamond formation – where, when and how? Lithos. 2015;220-223:200–220. Web of Science ®Google Scholar
Narayan RJ, Boehm RD, Sumant AV. Medical applications of diamond particles & surfaces. Mater Today. 2011;14(4):154–163. Web of Science ®Google Scholar
Mochalin VN, Shenderova O, Ho D, et al. The properties and applications of nanodiamonds. Nature Nanotech. 2012;7(1):11–23. Web of Science ®Google Scholar
Narayan J, Bhaumik A. Novel synthesis and properties of pure and NV-doped nanodiamonds and other nanostructures. Mater Res Lett. 2017;5(4):242–250. Web of Science ®Google Scholar
Dolmatov VY, Myllymäki V, Vehanen A, et al. Dependence of the detonation nanodiamond yield on the detonation process parameters. J Superhard Mater. 2019;41(5):355–359. Web of Science ®Google Scholar
Shvidchenko AV, Eidelman ED, Vul AY, et al. Colloids of detonation nanodiamond particles for advanced applications. Adv Colloid Interface Sci. 2019;268:64–81. PubMed Web of Science ®Google Scholar
Gorrini F, Cazzanelli M, Bazzanella N, et al. On the thermodynamic path enabling a room-temperature, laser-assisted graphite to nanodiamond transformation. Sci Rep. 2016;6:35244 PubMed Web of Science ®Google Scholar
Xiao J, Liu P, Yang GW. Nanodiamonds from coal under ambient conditions. Nanoscale. 2015;7(14):6114–6125. PubMed Web of Science ®Google Scholar
De Feudis M, Tallaire A, Nicolas L, et al. Large‐scale fabrication of highly emissive nanodiamonds by chemical vapor deposition with controlled doping by SiV and GeV centers from a solid source. Adv Mater Interfaces. 2020;7(2):1901408. Web of Science ®Google Scholar
Basso L, Cazzanelli M, Orlandi M, et al. Nanodiamonds: synthesis and application in sensing, catalysis, and the possible connection with some processes occurring in space. Appl Sci. 2020;10(12):4094. Google Scholar
Rehor I, Cigler P. Precise estimation of HPHT nanodiamond size distribution based on transmission electron microscopy image analysis. Diam Relat Mater. 2014;46:21–24. Web of Science ®Google Scholar
Stehlik S, Varga M, Ledinsky M, et al. Size and purity control of HPHT nanodiamonds down to 1 nm. J Phys Chem C. 2015;119(49):27708–27720. PubMed Web of Science ®Google Scholar
Dideikin AT, Aleksenskii AE, Baidakova MV, et al. Rehybridization of carbon on facets of detonation diamond nanocrystals and forming hydrosols of individual particles. Carbon. 2017;122:737–745. Web of Science ®Google Scholar
Lu Y, Huang G, Wang S, et al. A review on diamond-like carbon films grown by pulsed laser deposition. Appl Surf Sci. 2021;541:148573. Web of Science ®Google Scholar
Bakharev PV, Huang M, Saxena M, et al. Chemically induced transformation of chemical vapour deposition grown bilayer graphene into fluorinated single-layer diamond. Nat Nanotechnol. 2020;15(1):59–66. PubMed Web of Science ®Google Scholar
Cumont A, Pitt AR, Lambert PA, et al. Properties, mechanism and applications of diamond as an antibacterial material. Funct Diam. 2021;1(1):1–28. Google Scholar
Huang B-R, Wang M-J, Kathiravan D, et al. Interfacial effect of oxygen-doped nanodiamond on CuO and micropyramidal silicon heterostructures for efficient nonenzymatic glucose sensor. ACS Appl Bio Mater. 2018;1(5):1579–1586. PubMedGoogle Scholar
Huang F, Deng Y, Chen Y, et al. Anchoring Cu 1 species over nanodiamond-graphene for semi-hydrogenation of acetylene. Nat Commun. 2019;10:4431. PubMed Web of Science ®Google Scholar
Fang J, Wang H, Bao X, et al. Nanodiamond as efficient peroxidase mimic against periodontal bacterial infection. Carbon. 2020;169:370–381. Web of Science ®Google Scholar
Chen TM, Tian XM, Huang L, et al. Nanodiamonds as pH-switchable oxidation and reduction catalysts with enzyme-like activities for immunoassay and antioxidant applications. Nanoscale. 2017;9(40):15673–15684. PubMed Web of Science ®Google Scholar
Mogilnaya O, Ronzhin N, Artemenko K, et al. Nanodiamonds as an effective adsorbent for immobilization of extracellular peroxidases from luminous fungus neonothopanus nambi to construct a phenol detection system. Biocatal Biotransform. 2019;37(2):97–105. Web of Science ®Google Scholar
Vaijayanthimala V, Cheng P-Y, Yeh S-H, et al. The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent. Biomaterials. 2012;33(31):7794–7802. PubMed Web of Science ®Google Scholar
van der Laan K, Hasani M, Zheng T, et al. Nanodiamonds for in vivo applications. Small. 2018;14(19):1703838. PubMed Web of Science ®Google Scholar
Chong EYW, Ng CYP, Choi VWY, et al. A diamond nanocone array for improved osteoblastic differentiation. J Mater Chem B. 2013;1(27):3390–3396. PubMed Web of Science ®Google Scholar
Sutisna B, Janssens SD, Giussani A, et al. Block copolymer–nanodiamond coassembly in solution: towards multifunctional hybrid materials. Nanoscale. 2021;13(3):1639–1651. PubMed Web of Science ®Google Scholar
Jariwala DH, Patel D, Wairkar S. Surface functionalization of nanodiamonds for biomedical applications. Mater Sci Eng C. 2020;113:110996. PubMed Web of Science ®Google Scholar
Wei S, Li L, Du X, et al. Off–on nanodiamond drug platform for targeted cancer imaging and therapy. J Mater Chem B. 2019;7(21):3390–3402. Web of Science ®Google Scholar
Gu M, Toh TB, Hooi L, et al. Nanodiamond-mediated delivery of a G9a inhibitor for hepatocellular carcinoma therapy. ACS Appl Mater Interfaces. 2019;11(49):45427–45441. PubMed Web of Science ®Google Scholar
Gao G, Guo Q, Zhi J. Nanodiamond‐based theranostic platform for drug delivery and bioimaging. Small. 2019;15(48):1902238. PubMed Web of Science ®Google Scholar
Chan MS, Liu LS, Leung HM, et al. Cancer-cell-specific mitochondria-targeted drug delivery by dual-ligand-functionalized nanodiamonds circumvent drug resistance. ACS Appl Mater Interfaces. 2017;9(13):11780–11789. PubMed Web of Science ®Google Scholar
Simon J, Wolf T, Klein K, et al. Hydrophilicity regulates the stealth properties of polyphosphoester‐coated nanocarriers. Angew Chem Int Ed. 2018;57(19):5548–5553. PubMed Web of Science ®Google Scholar
Silva DD, Kaduri M, Poley M, et al. Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems. Chem Eng J. 2018;340:9–14. PubMed Web of Science ®Google Scholar
Merz V, Lenhart J, Vonhausen Y, et al. Zwitterion‐functionalized detonation nanodiamond with superior protein repulsion and colloidal stability in physiological media. Small. 2019;15(48):1901551. Web of Science ®Google Scholar
Madamsetty VS, Pal K, Keshavan S, et al. Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer. Nanoscale. 2019;11(45):22006–22018. PubMed Web of Science ®Google Scholar
Liao W-S, Ho Y, Lin Y-W, et al. Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel-and cetuximab-conjugated nanodiamond nanocomposite. Acta Biomater. 2019;86:395–405. PubMed Web of Science ®Google Scholar
Yang Y, Yuen M-F, Chen X, et al. Fabrication of arrays of high-aspect-ratio diamond nanoneedles via maskless ECR-assisted microwave plasma etching. CrystEngComm. 2015;17(14):2791–2800. Web of Science ®Google Scholar
Zhu X, Kwok SY, Yuen MF, et al. Dense diamond nanoneedle arrays for enhanced intracellular delivery of drug molecules to cell lines. J Mater Sci. 2015;50(23):7800–7807. Web of Science ®Google Scholar
Chen X, Zhu G, Yang Y, et al. A diamond nanoneedle array for potential high‐throughput intracellular delivery. Adv Healthc Mater. 2013;2(8):1103–1107. PubMed Web of Science ®Google Scholar
Zhu X, Yuen MF, Yan L, et al. Diamond‐nanoneedle‐array‐facilitated intracellular delivery and the potential influence on cell physiology. Adv Healthcare Mater. 2016;5(10):1157–1168. Web of Science ®Google Scholar
He G, Hu N, Xu AM, et al. Nanoneedle platforms: the many ways to pierce the cell membrane. Adv Funct Mater. 2020;30(21):1909890. Web of Science ®Google Scholar
Zhang Y, Gu Y, He J, et al. Ultrabright gap-enhanced raman tags for high-speed bioimaging. Nat Commun. 2019;10:1–12. PubMed Web of Science ®Google Scholar
Kim D, Jeong K, Kwon JE, et al. Dual-color fluorescent nanoparticles showing perfect color-specific photoswitching for bioimaging and super-resolution microscopy. Nat Commun. 2019;10:1–10. PubMed Web of Science ®Google Scholar
Torelli MD, Nunn NA, Shenderova OA. A perspective on fluorescent nanodiamond bioimaging. Small. 2019;15(48):1902151. PubMed Web of Science ®Google Scholar
Ho D, Wang C-HK, Chow EK-H. Nanodiamonds: the intersection of nanotechnology, drug development, and personalized medicine. Sci Adv. 2015;1(7):e1500439. PubMed Web of Science ®Google Scholar
Fang C, Vaijayanthimala V, Cheng C, et al. The exocytosis of fluorescent nanodiamond and its use as a long‐term cell tracker. Small. 2011;7(23):3363–3370. PubMed Web of Science ®Google Scholar
Alkahtani MH, Alghannam F, Jiang L, et al. Fluorescent nanodiamonds: past, present, and future. Nanophotonics. 2018;7(8):1423–1453. Web of Science ®Google Scholar
Reineck P, Lau DWM, Wilson ER, et al. Effect of surface chemistry on the fluorescence of detonation nanodiamonds. ACS Nano. 2017;11(11):10924–10934. PubMed Web of Science ®Google Scholar
Shenderova OA, Vlasov II, Turner S, et al. Nitrogen control in nanodiamond produced by detonation shock-wave-assisted synthesis. J Phys Chem C. 2011;115(29):14014–14024. Web of Science ®Google Scholar
Shenderova OA, Shames AI, Nunn NA, et al. Synthesis, properties, and applications of fluorescent diamond particles. J Vac Sci Technol B Nanotechnol Microelectron Mater Process Meas Phenom. 2019;37:30802. Web of Science ®Google Scholar
Morita M, Tachikawa T, Seino S, et al. Controlled synthesis of gold nanoparticles on fluorescent nanodiamond via electron-beam-induced reduction method for dual-modal optical and electron bioimaging. ACS Appl Nano Mater. 2018;1(1):355–363. Web of Science ®Google Scholar
Yoshino F, Amano T, Zou Y, et al. Preferential tumor accumulation of polyglycerol functionalized nanodiamond conjugated with cyanine dye leading to near‐infrared fluorescence in vivo tumor imaging. Small. 2019;15(48):1901930. Web of Science ®Google Scholar
Lila ASA, Nawata K, Shimizu T, et al. Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration. Int J Pharm. 2013;456(1):235–242. PubMedGoogle Scholar
Choi HS, Liu W, Misra P, et al. Renal clearance of nanoparticles. Nat Biotechnol. 2007;25(10):1165–1170. PubMed Web of Science ®Google Scholar
Hoshyar N, Gray S, Han H, et al. The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction. Nanomedicine. 2016;11(6):673–692. PubMed Web of Science ®Google Scholar
Gobet J, Volpe P-N, Dubois M-A. Friction coefficient of diamond under conditions compatible with microelectromechanical systems applications. Appl Phys Lett. 2016;108(12):124103. Web of Science ®Google Scholar
Shuai C, Li Y, Wang G, et al. Surface modification of nanodiamond: toward the dispersion of reinforced phase in poly-l-lactic acid scaffolds. Int J Biol Macromol. 2019;126:1116–1124. PubMed Web of Science ®Google Scholar
Morimune-Moriya S, Yada S, Kuroki N, et al. Strong reinforcement effects of nanodiamond on mechanical and thermal properties of polyamide 66. Compos Sci Technol. 2020;199:108356. Web of Science ®Google Scholar
Zhang F, Song Q, Huang X, et al. A novel high mechanical property PLGA composite matrix loaded with nanodiamond–phospholipid compound for bone tissue engineering. ACS Appl Mater Interfaces. 2016;8(2):1087–1097. PubMed Web of Science ®Google Scholar
Feng P, Kong Y, Yu L, et al. Molybdenum disulfide nanosheets embedded with nanodiamond particles: co-dispersion nanostructures as reinforcements for polymer scaffolds. Appl Mater Today. 2019;17:216–226. Web of Science ®Google Scholar
Novoselov KS, Geim AK, Morozov SV, et al. Electric field effect in atomically thin carbon films. Science (80. 2004;306(5696):666–669. PubMed Web of Science ®Google Scholar
Kumar R, Sahoo S, Joanni E, et al. Heteroatom doped graphene engineering for energy storage and conversion. Mater Today. 2020;39:47–65. Web of Science ®Google Scholar
Yang W, He C, Zhang L, et al. Growth, characterization, and properties of nanographene. Small. 2012;8(9):1429–1435. PubMed Web of Science ®Google Scholar
Han P, Yao X, Müllen K, et al. Size-dependent electron transfer from atomically defined nanographenes to metal oxide nanoparticles. Nanoscale. 2020;12(30):16046–16052. PubMed Web of Science ®Google Scholar
Chen L, Hernandez Y, Feng X, et al. From nanographene and graphene nanoribbons to graphene sheets: chemical synthesis. Angew Chem Int Ed. 2012;51(31):7640–7654. PubMed Web of Science ®Google Scholar
Jassas RS, Mughal EU, Sadiq A, et al. Scholl reaction as a powerful tool for the synthesis of nanographenes: a systematic review. RSC Adv. 2021;11(51):32158–32202. PubMed Web of Science ®Google Scholar
Vo TH, Shekhirev M, Kunkel DA, et al. Bottom-up solution synthesis of narrow nitrogen-doped graphene nanoribbons. Chem Commun. 2014;50(32):4172–4174. PubMed Web of Science ®Google Scholar
Tan Y-Z, Yang B, Parvez K, et al. Atomically precise edge chlorination of nanographenes and its application in graphene nanoribbons. Nat Commun. 2013;4:2646. PubMed Web of Science ®Google Scholar
Fujii S, Enoki T. Nanographene and graphene edges: electronic structure and nanofabrication. Acc Chem Res. 2013;46(10):2202–2210. PubMed Web of Science ®Google Scholar
Manrique DZ, You JW, Deng H, et al. Quantum plasmon engineering with interacting graphene nanoflakes. J Phys Chem C. 2017;121(49):27597–27602. Web of Science ®Google Scholar
Banerjee S, Bhattacharyya D. Electronic properties of nano-graphene sheets calculated using quantum chemical DFT. Comput Mater Sci. 2008;44(1):41–45. Web of Science ®Google Scholar
Robertson NM, Toscano AE, LaMantia VE, et al. Unlocked nucleic acids for miRNA detection using two dimensional nano-graphene oxide. Biosens Bioelectron. 2017;89:551–557. PubMed Web of Science ®Google Scholar
Qi L, Fan Y-Y, Wei H, et al. Graphene oxide-enhanced and proflavine-probed fluorescence polarization biosensor for ligand-RNA interaction assay. Sensors Actuators B Chem. 2018;257:666–671. Web of Science ®Google Scholar
Sanchez VC, Jachak A, Hurt RH, et al. Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol. 2012;25(1):15–34. PubMed Web of Science ®Google Scholar
Liu J, Cui L, Losic D. Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater. 2013;9(12):9243–9257. PubMed Web of Science ®Google Scholar
Ashraf MA, Peng W, Zare Y, et al. Effects of size and aggregation/agglomeration of nanoparticles on the interfacial/interphase properties and tensile strength of polymer nanocomposites. Nanoscale Res Lett. 2018;13(1):214. PubMedGoogle Scholar
Lee C, Wei X, Kysar JW, et al. Measurement of the elastic properties and intrinsic strength of monolayer graphene. Science. 2008;321(5887):385–388. PubMed Web of Science ®Google Scholar
Georgakilas V, Tiwari JN, Kemp KC, et al. Noncovalent functionalization of graphene and graphene oxide for energy materials, biosensing, catalytic, and biomedical applications. Chem Rev. 2016;116(9):5464–5519. PubMed Web of Science ®Google Scholar
Pérez EM, Martín N. π–π interactions in carbon nanostructures. Chem Soc Rev. 2015;44(18):6425–6433. PubMed Web of Science ®Google Scholar
Xiao F, Chen Z, Wei Z, et al. Hydrophobic interaction: a promising driving force for the biomedical applications of nucleic acids. Adv Sci. 2020;7(16):2001048. Web of Science ®Google Scholar
Sasidharan A, Panchakarla LS, Chandran P, et al. Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene. Nanoscale. 2011;3(6):2461–2464. PubMed Web of Science ®Google Scholar
Gao W, Alemany LB, Ci L, et al. New insights into the structure and reduction of graphite oxide. Nature Chem. 2009;1(5):403–408. PubMed Web of Science ®Google Scholar
Marcano DC, Kosynkin DV, Berlin JM, et al. Improved synthesis of graphene oxide. ACS Na. 2010;4(8):4806–4814. PubMed Web of Science ®Google Scholar
Jain VP, Chaudhary S, Sharma D, et al. Advanced functionalized nanographene oxide as a biomedical agent for drug delivery and anti-cancerous therapy: a review. Eur Polym J. 2021;142:110124. Web of Science ®Google Scholar
Wang A, Yu W, Huang Z, et al. Covalent functionalization of reduced graphene oxide with porphyrin by means of diazonium chemistry for nonlinear optical performance. Sci Rep. 2016;6:23325. PubMed Web of Science ®Google Scholar
Yu W, Sisi L, Haiyan Y, et al. Progress in the functional modification of graphene/graphene oxide: a review. RSC Adv. 2020;10(26):15328–15345. PubMed Web of Science ®Google Scholar
Hermanson GT. Bioconjugate techniques. London, Waltham, and San Diego: Academic Press; 2013. Google Scholar
Hutchins KM. Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes. R Soc Open Sci. 2018;5(6):180564. PubMed Web of Science ®Google Scholar
Liu Z, Robinson JT, Sun X, et al. PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc. 2008;130(33):10876–10877. PubMed Web of Science ®Google Scholar
Mugnano M, Lama GC, Castaldo R, et al. Cellular uptake of mildly oxidized nanographene for drug-delivery applications. ACS Appl Nano Mater. 2020;3(1):428–439. Web of Science ®Google Scholar
Li S, Zheng J, Chen D, et al. Yolk–shell hybrid nanoparticles with magnetic and pH-sensitive properties for controlled anticancer drug delivery. Nanoscale. 2013;5(23):11718–11724. PubMed Web of Science ®Google Scholar
Depan D, Shah J, Misra RDK. Controlled release of drug from folate-decorated and graphene mediated drug delivery system: synthesis, loading efficiency, and drug release response. Mater Sci Eng C. 2011;31(7):1305–1312. Web of Science ®Google Scholar
Sun X, Liu Z, Welsher K, et al. Nano-graphene oxide for cellular imaging and drug delivery. Nano Res. 2008;1(3):203–212. PubMed Web of Science ®Google Scholar
Vaidyanathan S, Chen J, Orr BG, et al. Cationic polymer intercalation into the lipid membrane enables intact polyplex DNA escape from endosomes for gene delivery. Mol Pharm. 2016;13(6):1967–1978. PubMedGoogle Scholar
Oskuee RK, Dabbaghi M, Gholami L, et al. Investigating the influence of polyplex size on toxicity properties of polyethylenimine mediated gene delivery. Life Sci. 2018;197:101–108. PubMed Web of Science ®Google Scholar
Ahn HH, Lee MS, Cho MH, et al. DNA/PEI nano-particles for gene delivery of rat bone marrow stem cells. Colloids Surfaces A Physicochem Eng Asp. 2008;313-314:116–120. Web of Science ®Google Scholar
Godbey WT, Wu KK, Mikos AG. Size matters: molecular weight affects the efficiency of poly (ethylenimine) as a gene delivery vehicle. J Biomed Mater Res. 1999;45(3):268–275. PubMed Web of Science ®Google Scholar
Imani R, Prakash S, Vali H, et al. Polyethylene glycol and octa-arginine dual-functionalized nanographene oxide: an optimization for efficient nucleic acid delivery. Biomater Sci. 2018;6(6):1636–1650. PubMed Web of Science ®Google Scholar
Chertok B, David AE, Yang VC. Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration. Biomaterials. 2010;31(24):6317–6324. PubMed Web of Science ®Google Scholar
Zhu J, Tang A, Law LP, et al. Amphiphilic core-shell nanoparticles with poly (ethylenimine) shells as potential gene delivery carriers. Bioconjugate Chem. 2005;16(1):139–146. PubMed Web of Science ®Google Scholar
Feng L, Zhang S, Liu Z. Graphene based gene transfection. Nanoscale. 2011;3(3):1252–1257. PubMed Web of Science ®Google Scholar
Zhang L, Lu Z, Zhao Q, et al. Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI‐grafted graphene oxide. Small. 2011;7(4):460–464. PubMed Web of Science ®Google Scholar
Yang H-W, Huang C-Y, Lin C-W, et al. Gadolinium-functionalized nanographene oxide for combined drug and microRNA delivery and magnetic resonance imaging. Biomaterials. 2014;35(24):6534–6542. PubMed Web of Science ®Google Scholar
Zhao H, Ding R, Zhao X, et al. Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering. Drug Discov Today. 2017;22(9):1302–1317. PubMed Web of Science ®Google Scholar
Ovsianikov A, Khademhosseini A, Mironov V. The synergy of scaffold-based and scaffold-free tissue engineering strategies. Trends Biotechnol. 2018;36(4):348–357. PubMed Web of Science ®Google Scholar
Goenka S, Sant V, Sant S. Graphene-based nanomaterials for drug delivery and tissue engineering. J Control Release. 2014;173:75–88. PubMed Web of Science ®Google Scholar
Shin SR, Li Y-C, Jang HL, et al. Graphene-based materials for tissue engineering. Adv Drug Deliv Rev. 2016;105:255–274. PubMed Web of Science ®Google Scholar
Wu D, Samanta A, Srivastava RK, et al. Starch-derived nanographene oxide paves the way for electrospinnable and bioactive starch scaffolds for bone tissue engineering. Biomacromolecules. 2017;18(5):1582–1591. PubMed Web of Science ®Google Scholar
Yadav A, Erdal NB, Hakkarainen M, et al. Cellulose-derived nanographene oxide reinforced macroporous scaffolds of high internal phase emulsion-templated cross-Linked poly (ε-caprolactone). Biomacromolecules. 2020;21(2):589–596. PubMed Web of Science ®Google Scholar
Jo SB, Erdenebileg U, Dashnyam K, et al. Nano-graphene oxide/polyurethane nanofibers: mechanically flexible and myogenic stimulating matrix for skeletal tissue engineering. J Tissue Eng. 2020;11:204173141990042. Web of Science ®Google Scholar
McCaul M, Glennon T, Diamond D. Challenges and opportunities in wearable technology for biochemical analysis in sweat. Curr Opin Electrochem. 2017;3(1):46–50. Web of Science ®Google Scholar
Ferreira JJ, Fernandes CI, Rammal HG, et al. Wearable technology and consumer interaction: a systematic review and research agenda. Comput Hum Behav. 2021;118:106710. Web of Science ®Google Scholar
Wu Z-S, Tan Y-Z, Zheng S, et al. Bottom-up fabrication of sulfur-doped graphene films derived from sulfur-annulated nanographene for ultrahigh volumetric capacitance micro-supercapacitors. J Am Chem Soc. 2017;139(12):4506–4512. PubMed Web of Science ®Google Scholar
Zhang C, Kang T-H, Yu J-S. Three-dimensional spongy nanographene-functionalized silicon anodes for lithium ion batteries with superior cycling stability. Nano Res. 2018;11(1):233–245. Web of Science ®Google Scholar
Wu Q, Xie D-J, Zhang Y-D, et al. Mechanical properties and simulation of nanographene/polyvinylidene fluoride composite films. Compos Part B Eng. 2019;156:148–155. Web of Science ®Google Scholar
Liu X, Liu D, Lee J, et al. Spider-web-inspired stretchable graphene woven fabric for highly sensitive, transparent, wearable strain sensors. ACS Appl Mater Interfaces. 2019;11(2):2282–2294. PubMed Web of Science ®Google Scholar
Romero FJ, Castillo E, Rivadeneyra A, et al. Inexpensive and flexible nanographene-based electrodes for ubiquitous electrocardiogram monitoring. npj Flex Electron. 2019;3:12. Google Scholar
Toh C-T, Zhang H, Lin J, et al. Synthesis and properties of free-standing monolayer amorphous carbon. Nature. 2020;577(7789):199–203. PubMed Web of Science ®Google Scholar
Bhattarai B, Pandey A, Drabold DA. Evolution of amorphous carbon across densities: an inferential study. Carbon. 2018;131:168–174. Web of Science ®Google Scholar
Bhattarai B, Drabold DA. Amorphous carbon at low densities: an ab initio study. Carbon. 2017;115:532–538. Web of Science ®Google Scholar
Xiong Y, Schneider J, Ushakova EV, et al. Influence of molecular fluorophores on the research field of chemically synthesized carbon dots. Nano Today. 2018;23:124–139. Web of Science ®Google Scholar
Nufer S, Fantanas D, Ogilvie SP, et al. Percolating metallic structures templated on laser-deposited carbon nanofoams derived from graphene oxide: applications in humidity sensing. ACS Appl Nano Mater. 2018;1(4):1828–1835. Web of Science ®Google Scholar
Li X, Zhao L, Li P, et al. In-situ electron microscopy observation of electrochemical sodium plating and stripping dynamics on carbon nanofiber current collectors. Nano Energy. 2017;42:122–128. Web of Science ®Google Scholar
Li X, Zhang D, Xu X, et al. Tailoring the nanostructure of graphene as an oil-based additive: toward synergistic lubrication with an amorphous carbon film. ACS Appl Mater Interfaces. 2020;12(38):43320–43330. PubMed Web of Science ®Google Scholar
Zhao T, Ji X, Jin W, et al. Electromagnetic wave absorbing properties of aligned amorphous carbon nanotube/BaFe12O19 nanorod composite. J Alloys Compd. 2017;703:424–430. Web of Science ®Google Scholar
Yoo K, Miller B, Kalish R, et al. Electrodes of nitrogen‐incorporated tetrahedral amorphous carbon a novel thin‐film electrocatalytic material with diamond‐like stability. Electrochem Solid-State Lett. 1999;2(5):233. Google Scholar
Palomäki T, Peltola E, Sainio S, et al. Unmodified and multi-walled carbon nanotube modified tetrahedral amorphous carbon (ta-C) films as in vivo sensor materials for sensitive and selective detection of dopamine. Biosens Bioelectron. 2018;118:23–30. PubMed Web of Science ®Google Scholar
Peltola E, Wester N, Holt KB, et al. Nanodiamonds on tetrahedral amorphous carbon significantly enhance dopamine detection and cell viability. Biosens Bioelectron. 2017;88:273–282. PubMed Web of Science ®Google Scholar
Field SK, Jarratt M, Teer DG. Tribological properties of graphite-like and diamond-like carbon coatings. Tribol Int. 2004;37(11-12):949–956. Web of Science ®Google Scholar
Dong D, Jiang B, Li H, et al. Effect of graphite target power density on tribological properties of graphite-like carbon films. Appl Surf Sci. 2018;439:900–909. Web of Science ®Google Scholar
Zhu H, Hassan T, Kabir H, et al. Voltammetric pH sensor based on electrochemically modified pseudo-graphite. Analyst. 2020;145(22):7252–7259. PubMed Web of Science ®Google Scholar
Zhang X, Yu X, Wen K, et al. Multiplex lateral flow immunoassays based on amorphous carbon nanoparticles for detecting three fusarium mycotoxins in maize. J Agric Food Chem. 2017;65(36):8063–8071. PubMed Web of Science ®Google Scholar
Moyano A, Serrano-Pertierra E, Salvador M, et al. Carbon-Coated superparamagnetic nanoflowers for biosensors based on lateral flow immunoassays. Biosensors. 2020;10(8):80. PubMedGoogle Scholar
Hu Y, Domínguez CM, Bauer J, et al. Carbon-nanotube reinforcement of DNA-silica nanocomposites yields programmable and cell-instructive biocoatings. Nat Commun. 2019;10(1):5522 PubMedGoogle Scholar
Sobolev A, Valkov A, Kossenko A, et al. Bioactive coating on Ti alloy with high osseointegration and antibacterial Ag nanoparticles. ACS Appl Mater Interfaces. 2019;11(43):39534–39544. PubMed Web of Science ®Google Scholar
Kapat K, Shubhra QTH, Zhou M, et al. Piezoelectric nano‐biomaterials for biomedicine and tissue regeneration. Adv Funct Mater. 2020;30(44):1909045. Web of Science ®Google Scholar
Granek A, Monika M, Ozimina D. Diamond-like carbon films for use in medical implants. AIP Conf Proc. 2018;2017:020006. Google Scholar
Hajduga MB, Bobinski R. TiN, ZrN and DLC nanocoatings-a comparison of the effects on animals, in-vivo study. Mater Sci Eng C. 2019;104:109949. PubMed Web of Science ®Google Scholar
Hauert R, Thorwarth K, Thorwarth G. An overview on diamond-like carbon coatings in medical applications. Surf Coatings Technol. 2013;233:119–130. Web of Science ®Google Scholar
Choudhury D, Lackner J, Fleming RA, et al. Diamond-like carbon coatings with zirconium-containing interlayers for orthopedic implants. J Mech Behav Biomed Mater. 2017;68:51–61. PubMed Web of Science ®Google Scholar
Cloutier M, Mantovani D, Rosei F. Antibacterial coatings: challenges, perspectives, and opportunities. Trends Biotechnol. 2015;33(11):637–652. PubMed Web of Science ®Google Scholar
Glinel K, Thebault P, Humblot V, et al. Antibacterial surfaces developed from bio-inspired approaches. Acta Biomater. 2012;8(5):1670–1684. PubMed Web of Science ®Google Scholar
Yonezawa K, Kawaguchi M, Kaneuji A, et al. Evaluation of antibacterial and cytotoxic properties of a fluorinated diamond-like carbon coating for the development of antibacterial medical implants. Antibiotics. 2020;9(8):495. Web of Science ®Google Scholar
Chipaux M, van der Laan KJ, Hemelaar SR, et al. Nanodiamonds and their applications in cells. Small. 2018;14(24):1704263. Web of Science ®Google Scholar
Li Y, Feng L, Shi X, et al. Surface coating‐dependent cytotoxicity and degradation of graphene derivatives: towards the design of non‐toxic, degradable nano‐graphene. Small. 2014;10(8):1544–1554. PubMed Web of Science ®Google Scholar
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